.. ۞ Hydrolysis of membrane phosphatidylinositol bisphosphate (PIP2), which leads to an elevation of intracellular second messengers, diacylglycerol (DAG) and inositol trisphosphate (IP3, InsP3), which contains SH2 domains that enable it to interact with tyrosine phosphorylated RTKs and (PTKs) non-receptor enzymes, ۞ and receptor tyrosine kinases calcium release events (puffs) are known oncogenes (cancers) and proto-oncogenes (development) code for PTKs. Release can be considered to occur primarily within a thin, essentially two-dimensional subplasmalemmal endoplasmic reticulum shell. Potentiation of inositol trisphosphate-induced Ca2+ mobilization in Xenopus oocytes by cytosolic Ca2+. The influence of Ca2+ entry on the kinetics of InsP3-triggered oscillations in cytosolic calcium ([Ca2+]i) in gonadotrophs stimulated with gonadotropin-releasing hormone ۞(GnRH) the Thapsigargin-, [(thimerosal-), and ionomycin-]induced spiking (a sesquiterpene lactone from the plant Thapsia garganica, that underwent a Grob-type . fragmentation to give the cyclodecadiene 29, that gave triol 74, which can now be transformed to three natural products: trilobolide 14, nortrilobolide 15, and thapsivillosin F 16) in XBP1 spliced RNA end...(IP3, InsP3), diffuses to the endoplasmic reticulum, Ca2+ ions are the most widely employed second messengers which activates actin-myosin interaction.