SLC29A2 locus 11q13: [§§]; which consist of 12 exons, it is essential for nucleotide synthesis and contribute to nucleoside and nucleobase recycling by salvage pathways[1.] at the sinusoidal membrane at the canalicular† membrane in cells extensively metabolized natural nucleosides were not effluxed into the bile mucosa that lack de novo biosynthetic pathways, repression of ENT2 increases mucosal adenosine signaling and attenuates hypoxia-associated inflammation of the intestine. Cloning of a DER gene termed HNP36 was by serum or growth factor stimulation of cells from delayed-early response (DER) genes induced by immediate-early response (IER) genes. This predicted protein is 50% similar to the C-terminal 331 amino acids of the yeast protein FUN26, ENT2 mRNA is expressed in adult ovary and ovarian tumors and in fetal brain and heart. The N-terminal region of ENT proteins is the major site of 3-prime-deoxy-nucleoside interaction used in human immunodeficiency virus (HIV) therapy might also contribute to the development of adipose tissue alterations leading to lipodystrophy[1.], no relationship between mRNA levels and in vitro fludarabine cytotoxicity as well as its cytocidal effect and in antimetabolite drug resistance was observed, HNP36 is a truncated form of ENT2 encoding a homologous ei-type transporter low overall genetic diversity in SLC29A2 makes it unlikely that variation in the coding region contributes significantly to clinically observed differences in drug response. Found a correlation between hENT2 expression and induction of TIGAR-C12orf5 locus 12p13.3: [§§]; (TP53-induced glycolysis and apoptosis regulator) after fludarabine treatment in chronic lymphocytic leukemia cells, it shares similarity with fructose bisphosphatases availability affects the regulation of enzymes involved in nonoxidative glucose disposal including PGM (phosphoglycerate mutase) in the regulation of glucose metabolism and autophagy endogenous TIGAR expression sensitized cells to p53-induced death both branches (glycolysis and apoptosis) of the bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase hCG_2015138 Homo sapiens / homologs: PGAM1 are of considerable medical interest.