Human ferritins, Ferritin Light Chain

Ferritin Light Chain
A hollow sphere that permits entry of a variable amount of iron for storage as ferric hydroxide phosphate complexes. 2FG4

Human ferritins are a hollow sphere that permits entry of ferric hydroxide phosphate complexes into a hollow cavity to bind at the ferroxidase center (FERROPORTIN~ 1ZJ8). The H and L subunits are not functionally interchangeable, Ferritin Light Chain locus: 19q13.3-q13.4 [§§] have different mRNA molecules the heavy subunit (rich in human heart ferritin) is located on chromosome 11. These mutations are responsible for the diseases hereditary haemochromatosis (HFE) (autosomal recessive) and Hyperferritinemia syndrome are light-diffracting ferritin crystals. Iron chaperones poly(rC) binding protein-1 (PCBP1) are needed for delivery of iron to ferritin. In plant cells it is found in chloroplasts and other plastids.