Histone acetyltransferase KAT5 also known as Tip60 belongs to the MYST protein family homologous to those of MOZ related to yeast Sas2 locus: 11q13: [§§]. TIP60 represses apoptosis, but also an interaction partner of the Mdm2 oncoprotein , p53 induces (exogenous and endogenous) either cell-cycle, TIP60 on chromatin is decreased following DNA damage after cell death PDCD5 (programmed cell death 5) functions as a Tip60 coactivator and accumulate after exposure to ionizing radiation (IR). A catalytic subunit of the NuA4 histone acetyltransferase complex and a conserved mechanism GCN5 interacts with HTATTIP/TIP60 is a component of the NuA4. Tip60 and HDAC7, interact with each other and repress transcription. A complex formed by Tip60, EPC1, and ING3 is sufficient to reconstitute a trimericHDAC1 complex as transcriptional repressors in robust nucleosomal HAT (nuclear histone acetyltransferase) activity in vitro the amyloid beta (A4) precursor-like protein 2 (APLP2) induces apoptosis via Tip60 in H4 cells, the general transcription factor TFIID, PCAF complex contains proteins that have histone-like domains. NPAT recruits the TRRAP-Tip60 complex to histone gene promoters. Down-regulation of the tetraspaninKAI1 transcription factor by which phorbol 12-myristate 13-acetate (PMA) up-regulates KAI1, induces recruitment of TIP49 (RuvB-like 1 (E. coli))/Pontin activator complexes to the same motif.